Strain Name |
NOD.CB17-PrkdcscidIl2rgtm1BcgenFcgrttm1(FCGRT)Bcgen/Bcgen
|
Common Name |
B-NDG hFcRn mice |
Background | B-NDG | Catalog number | 111922 |
Related Genes |
FCGRT (Fc fragment of IgG receptor and transporter) |
Protein expression analysis
Strain specific analysis of FcRn expression in B-NDG mice and B-NDG hFcRn mice by western blot. Liver, kidney and spleen were collected from B-NDG mice (+/+) and homozygous B-NDG hFcRn mice (H/H) and analyzed by western blot with species-specific anti-FcRn antibody. Mouse FcRn was detectable in B-NDG mice (+/+). Human FcRn was detectable only in homozygous B-NDG hFcRn mice (H/H) but not in B-NDG mice (+/+).
Serum half-life of antibody drug in B-NDG hFcRn mice
Pharmacokinetics of YERVOY-analog (isotype: human IgG1) in B-NDG hFcRn mice.